Search results for "multi-scale modeling"

showing 3 items of 3 documents

Towards human cell simulation

2019

The faithful reproduction and accurate prediction of the phe-notypes and emergent behaviors of complex cellular systems are among the most challenging goals in Systems Biology. Although mathematical models that describe the interactions among all biochemical processes in a cell are theoretically feasible, their simulation is generally hard because of a variety of reasons. For instance, many quantitative data (e.g., kinetic rates) are usually not available, a problem that hinders the execution of simulation algorithms as long as some parameter estimation methods are used. Though, even with a candidate parameterization, the simulation of mechanistic models could be challenging due to the extr…

Constraint-based modelingAgent-based simulation; Big data; Biochemical simulation; Computational intelligence; Constraint-based modeling; Fuzzy logic; High-performance computing; Model reduction; Multi-scale modeling; Parameter estimation; Reaction-based modeling; Systems biology; Theoretical Computer Science; Computer Science (all)Computer scienceBiochemical simulationDistributed computingSystems biologyBig dataComputational intelligenceContext (language use)ING-INF/05 - SISTEMI DI ELABORAZIONE DELLE INFORMAZIONITheoretical Computer ScienceReduction (complexity)Big dataParameter estimationHigh-performance computingComputational intelligenceAgent-based simulationMathematical modelbusiness.industryModel reductionComputer Science (all)Multi-scale modelingINF/01 - INFORMATICASupercomputerVariety (cybernetics)Fuzzy logicReaction-based modelingbusinessSystems biology
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Modeling Drug Effects on Personalized 3D Models of the Heart: A Simulation Study

2010

[EN] The use of anti-arrhythmic drugs is common to treat heart rhythm disorders. Computational modeling and simulation are powerful tools that can be used to investigate the effects of specific drugs on cardiac electrophysiology. In this work a patient-specific anatomical heart model is built to study the effects of dofetilide, a drug that affects IKr current in cardiac cells. We study the multi-scale effects of the drug, from cellular to organ level, by simulating electrical propagation on tissue coupled cellular ion kinetics for several heart beats. Different cell populations configurations namely endocardial, midmyocardial and epicardial are used to test the effect of tissue heterogeneit…

Drugtherapy planningCardiac electrophysiologyHeart rhythm disordersComputer sciencemedia_common.quotation_subjectComputer Science (all)Cardiac electrophysiologyDofetilide3d modelmulti-scale modelingsimulationdrug cardio-toxicityTheoretical Computer ScienceTECNOLOGIA ELECTRONICAdrug modelingCardiac electrophysiology; drug cardio-toxicity; drug modeling; multi-scale modeling; simulation; therapy planning; Computer Science (all); Theoretical Computer SciencemedicineHeart beatAction potential durationNeurosciencemedicine.drugmedia_common
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An urban multi-­scale modeling using fuzzy evaluation of accessibility and morphological constraints

2008

International audience; Increasing mobility has contributed since a couple of years to favor urban sprawl. The negative impacts of urban sprawl are well known, in particular the increase of traffic flows and vulnerability of natural resources. Addressing those questions we propose a spatial decision support system based on a multi-scale approach. On the one hand, fractal geometry is used to determine where new urban developments are possible. Here, the central assumption is the fractal nature of urban growth allowing access to various types of amenities: central amenities (retailing, cultural offer...) and peripheral amenities (open landscape). On the other hand, the accessibility to retail…

urban developmentsfractal[SHS.GEO] Humanities and Social Sciences/GeographyMulti-scale modeling[SHS.GEO]Humanities and Social Sciences/Geographyplanning support systemaccessibility[ SHS.GEO ] Humanities and Social Sciences/Geography
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